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  1. Plasmomagnetic hybrid gold nanostructures as multifunctional nanocarriers for drug delivery, MRI contrast, and photothermal therapy of drug-resistant cancer cells
Plasmomagnetic hybrid gold nanostructures as multifunctional nanocarriers for drug delivery, MRI contrast, and photothermal therapy of drug-resistant cancer cells
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Plasmomagnetic hybrid gold nanostructures as multifunctional nanocarriers for drug delivery, MRI contrast, and photothermal therapy of drug-resistant cancer cells

Khafaji, M.

  1. DOI:10.1016/j.jddst.2024.106289
  2. Main Entry: Khafaji, M.
  3. Title:Plasmomagnetic hybrid gold nanostructures as multifunctional nanocarriers for drug delivery, MRI contrast, and photothermal therapy of drug-resistant cancer cells.
  4. Publisher:2024.
  5. Abstract:Presenting a simple efficient method, plasmomagnetic hybrid nanostructures (PNIPAM coated gold nanorods-dexpion hybrid nanostructure, PN-GDHNs) capable of serving as dual drug nanocarriers, MRI contrast, and photothermal agents for cancer therapy were synthesized. The cisplatin (CDDP) and doxorubicin (DOX) were loaded on PN-GDHNs and tested for their drug release, cytotoxicity, photothermal, and MRI contrast in vitro. We found that the drug release was controlled by pH and temperature, and the cytotoxicity was enhanced by the combination of chemotherapy and photothermal therapy. We also found that the PN-GDHNs could overcome the drug resistance of MCF7 breast cancer cells and improve the MRI contrast. We achieved a high cancer cell-killing efficiency of 97.3 ± 0.4 % in one dose with low drug concentration and laser power. Our results suggest that PN-GDHNs are promising multifunctional nanocarriers for cancer therapy applications. © 2024 Elsevier B.V
  6. Notes:Sharif Repository
  7. Subject:Cancer cells.
  8. Subject:Hybrid gold nanostructures.
  9. Subject:MRI contrast agent.
  10. Subject:Multifunctional nanocarriers.
  11. Subject:Plasmomagnetic nanostructures.
  12. Subject:Cisplatin.
  13. Subject:Doxorubicin.
  14. Subject:Gold nanorod.
  15. Subject:Nanocarrier.
  16. Subject:Nanomaterial.
  17. Subject:Prothrombin.
  18. Subject:Superparamagnetic iron oxide nanoparticle.
  19. Subject:Activated partial thromboplastin time.
  20. Subject:Animal experiment.
  21. Subject:Controlled study.
  22. Subject:Cytotoxicity.
  23. Subject:Drug delivery system.
  24. Subject:Drug efficacy.
  25. Subject:Drug release.
  26. Subject:Drug safety.
  27. Subject:Magnetic field.
  28. Subject:MCF-7 cell line.
  29. Subject:NCTC clone 929 cell line.
  30. Subject:Nuclear magnetic resonance imaging.
  31. Subject:Photothermal therapy.
  32. Subject:Surface plasmon resonance.
  33. Subject:Ultraviolet visible spectrophotometry.
  34. Subject:X ray diffraction.
  35. Added Entry:Bavi, O.
  36. Added Entry:Vossoughi, M.
  37. Added Entry:Sharif University of Technology.
  38. Source: Journal of Drug Delivery Science and Technology ; Volume 101 , 2024 ; 17732247 (ISSN)
  39. Web Site:https://www.sciencedirect.com/science/article/abs/pii/S1773224724009584

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